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OI Colloquium
Dr. George E. Fox
 University of Houston, Dept. of Biology & Biochemistry
Title Evolution of the Ribosome
Date31 / 03 / 2008
Time 2:30pm (Coffee served at 2:15pm)
PlaceMDCL-1110
Linkhttp://bchs.uh.edu/faculty.php?155622-961-5=gefox
Abstract The protein synthesis machinery is largely conserved in all domains of life and its origins likely predate the last common ancestor of all life as defined by usual phylogenetic trees. We are seeking to gain insight to ribosome origins by considering all relevant types of data including sequence, regulatory, and structural information. The modern machinery likely has both more and larger components than the ancestral machine. With this in mind, we separately seek to identify the portions of the ribosomal RNA and the individual proteins that are likely the oldest. Consistent with our predictions, it is found that the likely oldest ribosomal proteins in fact interact primarily with regions of the RNA that are likely the oldest.

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Origins Institute at McMaster University, 2004-2009
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